EXPERIENCE IN WATER SOLUBLE FORM QUERCETIN IN "TREATMENT BREAK" OF ACUTE PANCREATITIS

A.V. Chornomydz

Abstract


Acute pancreatitis is today one of the most common and most difficult of surgical diseases. The basis of pathogenetic "therapy break" is the concept of phased course of acute pancreatitis and the ability to stop the pathological cascade of reactions affecting the individual links pathogenetic process. The most promising direction in the treatment of acute pancreatitis is the impact on microcirculatory abnormalities in the pancreas and other organs and systems. Objective: To evaluate the clinical efficacy of water-soluble forms of quercetin in the complex conservative treatment of acute pancreatitis to prevent severe disease
Materials and methods. To investigate the efficacy based on quercetin in the prevention of severe pancreatitis we examined 128 patients with acute pancreatitis. 64 patients received additional medication water-soluble forms of quercetin. Investigated the performance of generally accepted laboratory tests. We evaluated the clinical efficacy of treatment and prevention of severe disease course.
Results and discussion. Found that the use of the first day course of acute pancreatitis water-soluble forms of quercetin we were able to reduce the length of stay of patients in hospital, to reduce the activity of the inflammatory process and the percentage of complications of the disease. Compared with the control group showed a reduction in rate of almost all complications of acute pancreatitis. Emphasizes a significant decrease in the percentage of patients with the presence of free fluid in the peritoneal and pleural cavities and the formation of acute pancreatic pseudocysts. Notable is also reducing the incidence of renal failure, especially in patients with severe disease. For setting effectiveness of the prevention of severe pancreatitis we analyzed the results of the clinical course and laboratory examinations of all patients of the group. Established that all 32 patients with predicted mild pancreatitis disease ran without going into severe. In the case of predicted severe acute pancreatitis motion using our developed scheme of treatment in 44% of patients the disease ran as easy pancreatitis, that without the development of complications.
Conclusion. The use of water-soluble forms of quercetin in the complex treatment of acute pancreatitis can be recommended for use for the prevention of severe disease.


Keywords


acute pancreatitis; quercetin; severity of the disease

References


Ананко О.А. Нове і старе в лікуванні та діагностиці гострого панкреатиту. Погляд на проблему з точки зору доказової медицини / О.А. Ананко // Укр. Мед. Часопис. – 2007. – № 6 (62) – С.59-62

Билык О.В. Биофлавоноид кверцетин и перспективы его использования в медицине / О.В. Билык, В.К. Рыбальченко, Б.П. Романюк // Загальна патологія та патологічна фізіологія. – 2007. – Т. 2, №1. – С. 4.8

Гальперин Э.И. Панкреонекроз: неиспользованные резервы лечения / Э.И. Гальперин, Т.Г. Дюжева // Анналы хирургической гепатологии – 2007. – Т. 12. – № 2. – С. 46-51.

Кочетова Л. В. Метаболическая коррекция в комплексном лечении больных острым панкреатитом / Л.В. Кочетова, С.С. Дунаевская // Казанский мед.ж.. 2011. №92. [Электронный ресурс] – Режим доступу: http://cyberleninka.ru/article/n/metabolicheskaya-korrektsiya-v-kompleksnom-lechenii-bolnyh-ostrym-pankreatitom

Острый панкреатит [под. ред. А.М. Шулутко, В.И. Семикова]. – Москва: ГОУ ВПО Первый московский государственный медицинский университет им. И.М. Сеченова. – 2010. – 35с.

Острый панкреатит: руководство для врачей / под ред. проф. Э.В. Недашковского. — М. : ГЭОТАР-Медиа, 2009. — 272 с.

Русин В.І. Оцінка важкості гострого панкреатиту / В.І. Русин, С.С. Філіп, С.М. Чобей // Науковий вісник Ужгородського університету, серія «Медицина» – 2012 – № 2 (44). – С. 118-121

Стандарти надання медичної допомоги хворим з невідкладними хірургічними захворюваннями органів черевної порожнини : Наказ МОЗ України № 297 від 02.04.2010 [Электронный ресурс] – Режим доступу: http://www.surgery_2_fipo.dsmu.edu.ua/

Толстой А.Д. Возможности «обрыва» деструктивного процесса на ранних стадиях панкреонекроза / А.Д. Толстой, Р.В. Гольцов // Хирургия. – 2006. – № 2. – С. 29–31.

Толстой А.Д. Концепция "обрыва" панкреонекроза — ключ к решению проблемы деструктивного панкреатита / А.Д. Толстой, В.Б. Краснорогов, В.Р. Гольцов и др. // Вестн. хир. им. И.И. Грекова. – 2001. – № 6. – С.26-30.

Хомерики Н.М. Патогенетически обоснованные подходы к лечению панкреатитов / Н.М. Хомерики, С.Г. Хомерики // Фарматека. – 2007. – № 13(147). – С. 74-78.

Anaya-Ayala J.E. Severe acute pancreatitis: prognosis and treatment implications / Anaya-Ayala, M. Porres-Aguilar, C.F. Mora-Loya [et al.] // Rev. Gastroenterol. Mex. – 2008. – Vol. 73, N 1. – P. 40 – 46.

Banks P.A. Practice guidelines in acute pancreatitis / P.A. Banks, M.L. Freeman // Am J Gastroenterol – 2006 – № 101. – Р. 2379–2400.

Bo-Guang Fan Acute pancreatitis / Bo-Guang Fan, Åke Andrén-Sandberg // North American Journal of Medical Sciences. – 2010. –V.2., №. 5. – P. 211-214

Johnson C.D. Pancreatic disease: Basic Science and clinical manegment / C.D. Johnson, C.W. Imrie. — London: Springer-Verlag, 2004. – 490 p.

Lankisch P.G. Pharmacological prevention and treatment of acute pancreatitis: where are we now? / P.G. Lankisch, M.M. Lerch // Dig Dis. – 2006. – № 24(1-2). – Р. 148 – 159.

Takeda K. JPN Guidelines for the management of acute pancreatitis: medical management of acute pancreatitis / K. Takeda, T. Takada, Y. Kawarada // J. Hepatobiliary Pancreat Surg. – 2006. – № 13(1). – Р. 42-47.

Whitcomb D.C. Clinical practice. Acute pancreatitis / D.C. Whitcomb // N Engl J Med. – 2006. – V.354. – P. 2142-2150




DOI: https://doi.org/10.22141/1997-2938.3-4.26-27.2014.83189

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 UKRAINIAN JOURNAL OF SURGERY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru