Neuroendocrine Tumors of the Stomach — General Clinical and Endoscopic Aspects (Literature Review)

Ya.B. Shvydky

Abstract


Neuroendocrine tumors of the stomach constitute only a minority of tumors of this localization. However, because of the growth rate, their visual similarity to the epithelial polyps, features of clinical pattern and course they are complex problem. Advances in biochemical and imaging diagnosis and drug therapy in recent decades has led to the creation of clinical guidelines for this disease in different countries. Formations of type 1 appear on the background of atrophic gastritis in the body of stomach, type 2 — against primary hypergastrinemia, such as Zollinger — Ellison syndrome. Neuroendocrine tumors of type 1 and 2 due to the predominantly benign course is often subject to endoscopic resection or even just observation, or subject to treatment is gastrinoma. At the same time, the masses of type 3 are sporadic, and are classified as neuroendocrine cancer and should be treated like a cancer of the stomach, depending on the stage. Advanced and multiple lesions are treated with long-acting somatostatin analogues.


Keywords


neuroendocrine tumors; stomach; diagnosis; treatment

References


Atrophic body gastritis patients with enterochromaffin-like cell dysplasia are at increased risk for the development of type I gastric carcinoid / Annibale B., Azzoni C., Corleto V.D. [et al.] // Eur. J. Gastroenterol. Hepatol. — 2001. — № 13. — P. 1449-1456.

Endocrine tumours of the stomach / Delle Fave G., Capurso G., Milione M. [et al.] // Best Pract. Res. Clin. Gastroenterol. — 2005. — № 19. — P. 659-673.

Guzу neuroendokrynne układu pokarmowego / Pod red. B. Kos-Kudła. — Gdańsk: Via Medica, 2010. — 362 s.

Endocrine tumours of the stomach. A temporal increase with proton pump introduction / Hodgson N., Konaris L.G., Livingstone A.S. [et al.] // Surg. Endosc. — 2005. — № 19. — P. 1610-1612.

Hoffmann K.M. Duodenal neuroendocrine tumors: Classification, functional syndromes, diagnosis and medical treatment / Hoffmann K.M., Furukawa M., Jensen R.T. // Best Pract. Res. Clin. Gastroenterol. — 2005. — № 19. — Р. 675-697.

Gastrinoma (duodenal and pancreatic) / Jensen R.T., Niederle B., Mitry E. [et al.] // Neuroendocrinology. — 2006. — № 84. — Р. 173-182.

Well-differentiated duodenal tumor/carcinoma (excluding gastrinomas) / Jensen R.T., Rindi G., Arbold R. [et al.] // Neuroendocrinology. — 2006. — № 84. — P. 165-172.

Carcinoids: the association of histologic growth pattern and survival / Johnson L.A., Lavin P., Moertel C.G. [et al.] // Cancer. — 1983. — № 51. — P. 882-889.

Kaltsas G.A. The diagnosis and medical management of neuroendocrine tumours / Kaltsas G.A., Besser G.M., Grossman A.B. // Endocr. Rev. — 2004. — № 25. — P. 458-511.

The Pathologic Classification of Neuroendocrine Tumors. A Review of Nomenclature, Grading, and Staging Systems / Klimstra D.S., Modlin I.R., Coppola D. [et al.] // Pancreas. — 2010. — Vol. 39, № 6. — P. 707-712.

Klöppel G. Tumour biology and histopathology of neuroendocrine tumours / Klöppel G. // Best Pract. Res. Clin. Endocrinol. & Metabolism. — 2007. — № 21. — P. 15-31.

Zalecenia diagnostyczno-lecznicze w guzach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzуw Neuroendokrynnych) / Kos-Kudła B., Bolanowski M., Handkiewicz-Junak D. [et al.] // Endokrynol. Pol. — 2008. — Vol. 59 (1). — S. 41-56.

NANETS Treatment Guidelines Well-Differentiated Neuroendocrine Tumors of the Stomach and Pancreas / Kulke M.H., Anthony L.B., Bushnell D.L. [et al.] // Pancreas. — 2010. — Vol. 39 (6). — P. 735-751.

Modlin I.M. A 50-year analysis od 562 gastric carcinoid: small tumor or large problem? / Modlin I.M., Lye K.D., Kidd M. // Am. J. Gastroenterol. — 2004. — № 99. — Р. 23-32.

Modlin I.M. A 5-decade analysis of 13,715 carcinoid tumors / Modlin I.M., Lye K.D., Kidd M. // Cancer. — 2003. — № 97. — P. 934-959.

Plöckinger U. Biotherapy / Plöckinger U., Wiedenmann B. // Best Pract. Res. Clin. Endocrinol. Metab. — 2007. — № 21. — P. 145-162.

Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS) / Plöckinger U., Rindi G., Arnold R. [et al.] // Neuroendocrinology. — 2004. — № 80. — Р. 394-424.

Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs) / Ramage J.K., Ahmed A., Ardill J. [et al.] // Gut. — 2012. — Vol. 61 (1). — P. 6-32.

ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: prognostic evaluation by pathological analysis / Rindi G., Azzoni C., Larosa S. [et al.] // Gastroenterology. — 1999. — № 116. — P. 532-542.

Well-differentiated gastric tumors/carcinomas / Ruszniewski P., Delle Fave G., Cadiot G. [et al.] // Neuroendocrinology. — 2006. — № 84. — P. 158-164.

Guzy endokrynne żołądka i dwunastnicy z uwzględnieniem gastrinoma (zasady postępowania rekomendowane przez Polską Sieć Guzow Neuroendokrynnych) / Rydzewska G., Cichocki A., Ćwikła J. [et al.] // Endokrynol. Pol. — 2008. — Vol. 59, № 1. — S. 57-67.

Solcia E., Bordi C., Creutzfeldt W. et al. Histopathological classification of nonantral gastric endocrine growths in man / Solcia E., Bordi C., Creutzfeldt W. [et al.] // Digestion. — 1988. — № 41. — P. 185-200.

Hyperplastic, dysplastic and neoplastic enterochromaffin-like-cell proliferation on the gastrin mucosa / Solcia E., Fiocca R., Villani L. [et al.] // Am. J. Surg. Pathol. — 1995. — № 19 (supl. 1). — P. S1-7.

Sweeney E.C. Atypical gastric carcinoids / Sweeney E.C., McDonnell L. // Histopathology. — 1980. — № 4. — P. 215-224.

NANETS Consensus Guidelines for the Diagnosis of Neuroendocrine Tumor / Vinik A.I., Woltering E.A., Warner R.R.P. [et al.] // Pancreas. — 2010. — Vol. 39 (6). — P. 707-712.




DOI: https://doi.org/10.22141/1997-2938.4.23.2013.86745

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 UKRAINIAN JOURNAL OF SURGERY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru