Postresection Liver Failure: Modern Problems of Definition, Epidemiology, Pathogenesis, Risk Factors Assessment, Prevention and Treatment

V.A. Vishnevsky, Yu.A. Kovalenko, O.I. Andreytseva, R.Z. Ikramov, M.G. Yefanov, N.A. Nazarenko, K.A. Tupikin

Abstract


The current state of the problem of postresection liver failure for the last 20 years is presented in the literary review. The article shows that serious difficulties at interpretation of treatment outcomes for these patients are directly connected with absence of general definition of considered concept. An inadequate quantity and/or quality of residual liver volume are key events in development of postresection liver failure. Main risk factors are presence of pre-existing liver disease, small remnant liver volume, as well as certain additional conditions. To prevent the development of liver failure, a comprehensive pre-operative evaluation, which includes clinical, biochemical, volume and functional data, is extremely important. Preventive measures are most effective when they are used at all stages of the perioperative management of patients. Treatment of postresection liver failure includes all possible ways that are used in the therapy of acute liver failure.


Keywords


postresection liver failure; risk factors; small remnant liver syndrome; prevention, treatment

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DOI: https://doi.org/10.22141/1997-2938.3.22.2013.87432

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