Adsorption-rheological properties of blood in patients with varicose vein during surgical treatment
Background. The pathogenesis of varicose disease has not been studied enough. Disruption of vascular matrix proteins, which undergo proteolytic processing, change the physico-chemical properties of venous blood. Objective: to study the serum adsorption-rheological state in varicose vein of the lower extremities and to evaluate the dynamics of the indices during surgical treatment of varicose veins. Materials and methods. The study included 102 patients (13 % men and 87 % women, average age 52 years old) who were treated for clinical class C2–C5. In 79 % of cases endovascular laser coagulation was performed, and in 21 % standard phlebectomy. Results. Varicose veins are associated with increased levels of low-density lipoprotein, the bulk viscosity, triglycerides, fibrinogen, cholesterol, surface relaxation on a background of decreased surface viscosity, surface elasticity and modulus of viscoelasticity in patients with varicose veins of lower extremities, which is observed in 100, 96, 74, 73, 65, 50, 44, 37, 52, 46 and 49 % of patients, respectively. Venous blood adsorption-rheological indicators interrelate, are associated with gender and age of patients and determined by the aggregate diameter of the segments of vein trunk, by the striping length and by the comorbidity nature. Relaxation, interphase activity and viscoelasticity parameters may have prognostic value. Integral dynamics of physical and chemical parameters does not depend on crossectomy performed performed along with the endovenous laser coagulation, and to the first month after such operations the parameters of blood adsorption-rheological properties normalize. Conclusions. A low-power laser ablation with radiation 10 W or less promotes to reduction of the relaxation properties of venous blood serum in a month after surgery. Integrated physical-chemical parameters depend on the effect of the laser energy on the length and lumen area striping. And initial values of the bulk viscosity and surface elasticity have prognostic significance.
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