Adsorption-rheological properties of blood in patients with varicose vein during surgical treatment

Yu.O. Syniachenko, G.E. Samoilenko

Abstract


Background. The pathogenesis of varicose disease has not been studied enough. Disruption of vascular matrix proteins, which undergo proteolytic processing, change the physico-chemical properties of venous blood. Objective: to study the serum adsorption-rheological state in varicose vein of the lower extremities and to evaluate the dynamics of the indices during surgical treatment of varicose veins. Materials and methods. The study included 102 patients (13 % men and 87 % women, average age 52 years old) who were treated for clinical class C2–C5. In 79 % of cases endovascular laser coagulation was performed, and in 21 % standard phlebectomy. Results. Varicose veins are associated with increased levels of low-density lipoprotein, the bulk viscosity, triglycerides, fibrinogen, cholesterol, surface relaxation on a background of decreased surface viscosity, surface elasticity and modulus of viscoelasticity in patients with varicose veins of lower extremities, which is observed in 100, 96, 74, 73, 65, 50, 44, 37, 52, 46 and 49 % of patients, respectively. Venous blood adsorption-rheological indicators interrelate, are associated with gender and age of patients and determined by the aggregate diameter of the segments of vein trunk, by the striping length and by the comorbidity nature. Relaxation, interphase activity and viscoelasticity parameters may have prognostic value. Integral dynamics of physical and chemical parameters does not depend on crossectomy performed performed along with the endovenous laser coagulation, and to the first month after such operations the parameters of blood adsorption-rheological properties normalize. Conclusions. A low-power laser ablation with radiation 10 W or less promotes to reduction of the relaxation properties of venous blood serum in a month after surgery. Integrated physical-chemical parameters depend on the effect of the laser energy on the length and lumen area striping. And initial values of the bulk viscosity and surface elasticity have prognostic significance.


Keywords


blood; adsorption; rheology; varicosity; treatment

References


Atasoy MM. Fill and aspirate foam sclerotherapy (FAFS): a new approach for sclerotherapy of large superficial varicosities concomitant to endovenous laser ablation of truncal vein. Clin Radiol 2015;70(1):48-53. doi: 10.1016/j.crad.2014.09.013.

Brzozowska AM, Spruijt E, de Keizer A, Cohen Stuart MA. On the stability of the polymer brushes formed by adsorption of ionomer complexes on hydrophilic and hydrophobic surfaces. J Colloid Interface Sci 2011;353(2);380-91. doi: 10.1016/j.jcis.2010.09.074.

Dash U, Misra PK. Evidence in favor of formation of hydrophobic complexes in aqueous solution. J Colloid Interface Sci 2011; 357(2):407-18. doi: 10.1016/j.jcis.2011.01.087.

Douillard R, Daoud M. State equation of -casein at the air/water interface. J Coll Interf Sci 2011; 163:277-88.

Fernando RS, Muthu C. Adoption of endovenous laser treatment as the primary treatment modality for varicose veins: the Auckland City Hospital experience. NZ Med J 2014;127(1399):43-50.

Kao P, Parhi P, Krishnan A, Noh H. Volumetric interpretation of protein adsorption: Interfacial packing of protein adsorbed to hydrophobic surfaces from surface-saturating solution concentrations. Biomaterials 2011;32(4):969-78. doi: 10.1016/j.biomaterials.2010.09.075.

Kazakov VN. Interfacial rheology of biological liquids: application in medical diagnostics and treatment monitoring. / Interfacial rheology / Ed. R.Miller, L.Liggieri. - Brill: Leiden-Boston, 2009:519-66.

Kelleher DT, Lane R, Franklin IJ, Davies AH. Socio-economic impact of endovenous thermal ablation techniques Lasers Med Sci 2014;29(2):493-9. doi: 10.1007/s10103-013-1453-8.

Khodabandehlou T, Boisseau MR, Le Devehat C. Blood rheology as a marker of venous hypertension in patients with venous disease. Clin Hemorheol Microcirc 2011;30(3-4):307-12.

Klonizakis M, Tew G, Michaels J, Saxton J. Impaired microvascular endothelial function is restored by acute lower-limb exercise in post-surgical varicose vein patients. Microvasc Res 2010;77(2):158-62. doi: 10.1016/j.mvr.2008.09.009.

Kohno K, Niihara H, Hamano T. Standing posture at work and overweight exacerbate varicose veins. J Dermatol 2014;41(11):964-8. doi: 10.1111/1346-8138.12643.

Koos E, Willenbacher N. Capillary forces in suspension rheology. Science 2011;331(6019):897-900. doi: 10.1126/science.1199243.

Koppensteiner R. Hemorheology and angiology. Fortschr Med 2012;110(7):108-10. doi: 10.1371/journal.pone.0129666.

Kotsmar C, Pradines V, Alahverdjieva VS, Aksenenko EV. Thermodynamics, adsorption kinetics and rheology of mixed protein-surfactant interfacial layers. Adv Colloid Interface Sci 2009;150(1):41-54. doi: 10.1016/j.cis.2009.05.002.

Kovalchuk VI, Aksenenko V, Miller R, Fainerman VB. Surface dilational rheology of mixed adsorption layers of proteins and surfactant at liquid interfaces / In: Interfacial Rheology [Ed. R.Miller and L.Liggieri].-Brill Publ., Leiden, 2009:332-71.

Kuet ML, Lane TR, Anwar MA, Davies AH. Comparison of disease-specific quality of life tools in patients with chronic venous disease. Phlebology 2014;29(10):648-53. doi: 10.1177/0268355513501302.

Liu C, Hao J, Wu Z. Phase behavior and rheological properties of salt-free catanionic surfactant mixtures in the presence of bile acids. J Phys Chem B 2010;114(30):9795-804. doi: 10.1021/jp103916a.

Lozano Sanchez FS, Sanchez Nevarez I, Gonzalez-Porras JR. Quality of life in patients with chronic venous disease: influence of the socio-demographical and clinical factors. Int Angiol 2013;32(4):433-41.

Lucassen-Reynders EH, Benjamins J, Fainerman VB. Dilational rheology of protein films adsorbed at fluid interfaces. Curr Op Coll Interf Sci 2010;15:264-70.

Noskov BA, Loglio G, Miller R. Dilational surface visco-elasticity of polyelectrolyte/surfactant solutions: Formation of heterogeneous adsorption layers Adv Colloid Interface Sci 2011;163(3):50-5. doi: 10.1016/j.cis.2011.02.010.

Piazza G. Varicose veins. Circulation 2014;130(7):582-7. doi: 10.1161/CIRCULATIONAHA.113.008331

Pradines V, Fainerman VB, Aksenenko EV, Krogel J. Adsorption of protein-surfactant complexes at the water/oil interface. Langmuir 2011;27(3):965-71. doi: 10.1021/la1040757.

Segiet OA, Brzozowa M, Piecuch A. Biomolecular mechanisms in varicose veins development. Ann Vasc Surg 2014;30(10):122-7. doi: 10.1016/j.avsg.2014.10.009.

Shrestha RG, Shrestha LK, Matsunaga T, Shibayama M. Lipophilic tail architecture and molecular structure of neutralizing agent for the controlled rheology of viscoelastic fluid in amino acid-based anionic aurfactant aystem. Langmuir 2011;26(2):21-5. doi: 10.1021/la1048248.

Słoczynska K, Kozka M, Marona H. Rheological properties of young and aged erythrocytes in chronic venous disease patients with varicose veins. Clin Hemorheol Microcirc 2013;17(4):145-52. doi: 10.3233/CH-131715.

Spiliopoulos S, Theodosiadou V, Sotiriadi A, Karnabatidis D. Endovenous ablation of incompetent truncal veins and their perforators with a new radiofrequency system. Mid-term outcomes. Vascular 2014;12(12):134-41. doi: 10.1177/1708538114564462.

Tassie E, Scotland G, Brittenden J. Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial. Br J Surg 2014;101(12):1532-40. doi: 10.1002/bjs.9595.

Walma E. Varicoses: should invasive treatment be standard? Ned Tijdschr Geneeskd 2014;158:8299.

Weiss MA, Hsu JT, Neuhaus I, Sadick NS. Consensus for sclerotherapy. Dermatol Surg 2014;40(12):1309-18. doi: 10.1097/DSS.0000000000000225. Xu J, Shi GP. Vascular wall extracellular matrix proteins and vascular diseases. Biochim Biophys Acta 2014;1842(11):2106-19. doi: 10.1016/j.bbadis.2014.07.008.




DOI: https://doi.org/10.22141/1997-2938.1.32.2017.98503

Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 UKRAINIAN JOURNAL OF SURGERY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru